An advanced form of ozone therapy designed to clean and detoxify your blood.

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What is EBOO?

Extracorporeal blood oxygenation and ozonation (EBOO) is an advanced form of ozone therapy that uses specialized equipment to filter your blood and expose it to a controlled mixture of ozone and oxygen.1

Ozone (O3) is a molecule composed of three oxygen atoms with oxidative properties that is studied for its oxidative properties.2,3

How Does EBOO Work?

EBOO is being studied for its potential impact on antioxidant production, vascular health, and immune processes.  

Antioxidant Effects 
Research indicates that EBOO therapy could work as an antioxidant by causing a short-lived and mild form of oxidative stress. This stress seems to activate a protein called Nrf2, which, when switched on, helps boost the production of antioxidants to protect the body from damage caused by harmful molecules.4,5
Additionally, EBOO may trigger  preventative effects on age-related oxidative stress by helping to rebalance the reduction and oxidation equilibrium, which tends to become dysregulated as we age.6
Vascular Health
EBOO therapy may also improve vascular and blood-related functions. Exposing cells to ozone helps oxygen move across cell membranes to boost cellular respiration.7,8 
Immune Processes

Studies have also noted the potential for EBOO to improve immune response by helping to inactivate pathogens. Ozone can oxidize or damage the outer layer of bacterial cells, making them vulnerable to disruption. This process hinders the activity of enzymes in these pathogens, which can lead to bacteria dying off or the inhibition of fungal growth.9

Check out our EBOO treatment summary to learn more. 

Potential Benefits EBOO Ozone Therapy

Circulation Improvement
Immune System Regulation
Inflammation Reduction
Pathogen Defense

What To Expect from EBOO Ozone Therapy

Before EBOO Treatment

Follow these tips as you prepare for your treatment.

  1. Stay hydrated—Staying hydrated before your appointment helps with vein accessibility. 
  2. Eat a healthy meal—Try to eat a healthy meal filled with protein and nutritious fats to stabilize your blood sugar.
  3. Wear comfortable clothing—Your treatment may last up to 75 minutes. We recommend wearing loose, comfortable clothing. Additionally, wearing short sleeves helps with vein accessibility. 

During EBOO Treatment

EBOO is a three-part process that typically takes 60 to 75 minutes.10
  1. Blood is withdrawn via an IV and passes through a state-of-the-art filter. 
  2. Next, the filtered blood is  mixed with medical-grade ozone and exposed to UV light to activate ozone molecules. 
  3. Finally, the ozonated blood is readministered into the patient’s body via a second vein.

After EBOO Treatment

There is no “right” way to feel after treatment. Immediate responses vary from person to person.

You may feel:

  • A boost in energy, mental clarity, and/or pain relief
  • Lethargic and achy
  • No different

If you don’t feel 100% following your treatment, focus on rest and eating nutrient-dense meals.

Find out if ozone therapy is right for you.

EBOO and Ozone Therapy FAQ

While EBOO therapy is generally considered very safe, side effects may include nausea, vomiting, headache, and dizziness. In rare cases EBOO may lead to more serious complications, such as seizures and heart problems.11,12

This minimally invasive treatment is safe and most patients do not experience noticeable side effects. However, EBOO may not be for everyone. Certain health conditions and contraindications may make you ineligible for treatment. Contraindications include:

  • Pregnant or breastfeeding
  • Blood disorders (Hemophilia)
  • Severe hypertension
  • Ozone allergy
    massive and acute hemorrhage or apoplectic stroke
  • Hyperthyroidism
  • Anyone under the age of 18
  • Anyone currently taking ACE inhibitors
  • Anyone who has undergone surgery in the past three months

For a full list of contraindications please contact concierge@hudson.health.

The exact amount may vary by patient, but on average, one EBOO treatment can filter up to 2 liters.
Number of EBOO treatments is up to the medical provider’s discretion and will vary based each patient’s age, health, and condition. Your medical provider may recommend follow-up treatment cycles based on your condition.
On average, EBOO treatment takes up to one hour. However, this timing may vary by patient.

During your treatment cellular bi-product is filtered into a collection cup. You may have seen online claims that this cellular bi-product is made of heavy metals, microplastics, parasites and more. But researchers are still studying these filtered bi-products to pinpoint their consistency.  The contents (including color) of the bi-product collected in the cup may vary widely between patients and individual treatments. As we eagerly await conclusive research, we remain focused on how you respond to the treatment.

There is no single way you should expect to feel following your treatment. Immediate responses to EBOO are dependent on the person. Some patients feel an immediate boost in energy and mental clarity, as well as almost immediate pain relief. However, other patients have noted feeling lethargic and achy in the hours after their treatment. While some feel no different following their treatment. 

With EBOO, we focus on the cellular benefits that accrue over time, which may include immune regulation, vascular health, tissue support, and inflammation reduction.

If you don’t feel 100% following your treatment, focus on getting adequate rest and eating nutrient-rich meals. Light exercise is also good to incorporate into your daily routine, as it can help with circulation. Your doctor may offer additional tips and instructions, including recommended vitamins and supplements.

EBOO therapy may be combined with other therapies like NAD+, Methylene Blue, and advanced vitamin IVs. However, complementary treatments are recommended on an individual basis. Your provider will assess your unique needs before exploring supplemental ways to maximize the benefits of your EBOO treatment.


  1. Tricarico, G., & Travagli, V. (2021). The Relationship between Ozone and Human Blood in the Course of a Well-Controlled, Mild, and Transitory Oxidative Eustress. Antioxidants (Basel, Switzerland), 10(12), 1946. https://doi.org/10.3390/antiox10121946
  2. Bocci V, Larini A, Micheli V. Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis. J Altern Complement Med. 2005;11:257–265
  3. Travagli V., Zanardi I., Bernini P., Nepi S., Tenori L., Bocci V. Effects of ozone blood treatment on the metabolite profile of human blood. Int. J. Toxicol. 2010;29:165–174. doi: 10.1177/1091581809360069
  4. Bocci V, Larini A, Micheli V. Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis. J Altern Complement Med. 2005;11:257–265
  5. Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017;7(3):212-219. Published 2017 Oct 17. doi:10.4103/2045-9912.215752
  6. El-Sawalhi MM, Darwish HA, Mausouf MN, Shaheen AA. Modulation of age-related changes in oxidative stress markers and energy status in the rat heart and hippocampus: a significant role for ozone therapy. Cell Biochem Funct. 2013;31:518–525
  7. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. J Transl Med. 2011;9:66
  8. Bocci V, Zanardi I, Huijberts MS, Travagli V. Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy. Diabetes Metab Syndr. 2011;5:45–49
  9. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006;37:425–435
  10. Di Paolo N, Gaggiotti E, Galli F. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Rep. 2005;10(3):121-130. doi:10.1179/135100005X38888
  11. Bocci V. The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy. OZONE. 2010;75-84. Published 2010 Sep 24. doi:10.1007/978-90-481-9234-2_7
  12. Bocci V. The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy. OZONE. 2010;75-84. Published 2010 Sep 24. doi:10.1007/978-90-481-9234-2_7