EBOO

Extracorporeal Blood Oxygenation and Ozonation

What is EBOO?

Extracorporeal blood oxygenation and ozonation is an advanced form of ozone therapy that uses specialized equipment to filter your blood and expose it to a controlled mixture of ozone and oxygen.1
Ozone (O3) is a molecule composed of three oxygen atoms with oxidative properties that is studied for its oxidative properties.2,3

How Does EBOO Work?

EBOO is being studied for its potential impact on antioxidant production, vascular health, and immune processes.  

Antioxidant Effects 
Research indicates that EBOO therapy could work as an antioxidant by causing a short-lived and mild form of oxidative stress. This stress seems to activate a protein called Nrf2, which, when switched on, helps boost the production of antioxidants to protect the body from damage caused by harmful molecules.4,5
Additionally, EBOO may trigger  preventative effects on age-related oxidative stress by helping to rebalance the reduction and oxidation equilibrium, which tends to become dysregulated as we age.6
Vascular Health
EBOO therapy may also improve vascular and blood-related functions. Exposing cells to ozone helps oxygen move across cell membranes to boost cellular respiration.7,8 
Immune Processes
Studies have also noted the potential for EBOO to improve immune response by helping to inactivate pathogens. Ozone can oxidize or damage the outer layer of bacterial cells, making them vulnerable to disruption. This process hinders the activity of enzymes in these pathogens, which can lead to bacteria dying off or the inhibition of fungal growth.9

Potential Benefits of EBOO

Circulation Improvement
Immune System Regulation
Inflammation Reduction
Pathogen Defense

What to Expect During EBOO Treatment

EBOO is a three-part process that typically takes 60 to 75 minutes.10
  1. Blood is withdrawn via an IV and passes through a state-of-the-art filter. 
  2. Next, the filtered blood is  mixed with medical-grade ozone and exposed to UV light to activate ozone molecules. 
  3. Finally, the ozonated blood is readministered into the patient’s body via a second vein.

Find out if EBOO treatment is right for you.

FAQ

While EBOO therapy is generally considered very safe, side effects may include nausea, vomiting, headache, and dizziness. In rare cases EBOO may lead to more serious complications, such as seizures and heart problems.11,12

This minimally invasive treatment is safe and most patients do not experience noticeable side effects. However, EBOO may not be for everyone. Certain health conditions and contraindications may make you ineligible for treatment. Contraindications include:

  • Pregnant or breastfeeding
  • Blood disorders (Hemophilia)
  • Severe hypertension
  • Ozone allergy
    massive and acute hemorrhage or apoplectic stroke
  • Hyperthyroidism
  • Anyone under the age of 18
  • Anyone currently taking ACE inhibitors
  • Anyone who has undergone surgery in the past three months

For a full list of contraindications please contact concierge@hudson.health.

The exact amount may vary by patient, but on average, one EBOO treatment can filter up to 2 liters.
Number of EBOO treatments is up to the medical provider’s discretion and will vary based each patient’s age, health, and condition. Your medical provider may recommend follow-up treatment cycles based on your condition.
On average, EBOO treatment takes up to one hour. However, this timing may vary by patient.

 

  1. Tricarico, G., & Travagli, V. (2021). The Relationship between Ozone and Human Blood in the Course of a Well-Controlled, Mild, and Transitory Oxidative Eustress. Antioxidants (Basel, Switzerland), 10(12), 1946. https://doi.org/10.3390/antiox10121946
  2. Bocci V, Larini A, Micheli V. Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis. J Altern Complement Med. 2005;11:257–265
  3. Travagli V., Zanardi I., Bernini P., Nepi S., Tenori L., Bocci V. Effects of ozone blood treatment on the metabolite profile of human blood. Int. J. Toxicol. 2010;29:165–174. doi: 10.1177/1091581809360069
  4. Bocci V, Larini A, Micheli V. Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis. J Altern Complement Med. 2005;11:257–265
  5. Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017;7(3):212-219. Published 2017 Oct 17. doi:10.4103/2045-9912.215752
  6. El-Sawalhi MM, Darwish HA, Mausouf MN, Shaheen AA. Modulation of age-related changes in oxidative stress markers and energy status in the rat heart and hippocampus: a significant role for ozone therapy. Cell Biochem Funct. 2013;31:518–525
  7. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. J Transl Med. 2011;9:66
  8. Bocci V, Zanardi I, Huijberts MS, Travagli V. Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy. Diabetes Metab Syndr. 2011;5:45–49
  9. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006;37:425–435
  10. Di Paolo N, Gaggiotti E, Galli F. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Rep. 2005;10(3):121-130. doi:10.1179/135100005X38888
  11. Bocci V. The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy. OZONE. 2010;75-84. Published 2010 Sep 24. doi:10.1007/978-90-481-9234-2_7
  12. Bocci V. The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy. OZONE. 2010;75-84. Published 2010 Sep 24. doi:10.1007/978-90-481-9234-2_7